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Supplements To Support implantation During IVF

By MomMed | 12 July 2022 | 0 Comments

Once in-vitro fertilization of your egg and collected sperm gets a green signal, the next step is embryo transfer. Only if the embryo gets implanted in the wall of the uterus, the procedure is considered successful. However, due to a host of reasons, implantation failure is likely to happen. In this article, we will understand the reasons behind that and get an idea about a few supplements to help implantation,IVF.

What Causes Implantation Failure?

Your embryo can fail to get implanted either if it has some genetic disorders assessing which the body rejects it, or the uterus is not ready to accept the embryo. For issues with the embryo, the egg and sperm quality need to be analyzed.
But when it comes to the uterus, there can be several contributing factors to the failure of implantation. Some of the major ones include an inadequate thickness of the endometrial lining, oxidative stress on the cells of the uterine lining, inflammation, fibroids, blood clots, autoimmune conditions, and a decreased level of hormones important for implantation.
When your embryo is transferred, it is expected that you do not have a decent uterine environment that can be receptive to the embryo. To prepare it further certain supplements are recommended. However, they mostly deal with improving blood flow and making the endometrium favorable for implantation. If fibroids or any kind of autoimmune conditions are detected, separate approaches to treatment have to be taken.


Supplements To Help Implantation, IVF

Here is a list of supplements that can potentially increase the chances of implantation after embryo transfer.

1.Vitamin D

First on the list is vitamin D, one of the most important supplements for implantation. It is a fat-soluble vitamin that is known to absorb a range of important minerals like calcium, phosphorous, magnesium, and zinc.
Vitamin D is majorly produced when cholesterol on the skin gets exposed to sunlight. Adequate amounts of vitamin D play a crucial role in reproduction. The endometrium, which is the inner lining of the uterus has receptors for vitamin D. When the vitamin binds to its receptors, it leads to the production of estrogen that helps in implantation and reduces the chances of miscarriage.
Moreover, vitamin D has also been found to thicken the endometrial lining and increase blood flow to the uterus. Some studies report that the levels of vitamin D are also a contributing factor to the quality of embryos produced during IVF.

2.Vitamin E

Vitamin E is known for its antioxidant properties. It is often used to maintain healthy skin, hair, and blood cells. It is capable of doing this by keeping oxidative damage at bay. However, it has also shown positive results as a supplement that can increase the chances of implantation.
The endometrium has to be at least 8mm thick in order to enable the embryo to get implanted post embryo transfer. In most cases, an IVF treatment fails due to the lack of required thickness of the uterine lining.
Vitamin E helps in thickening the endometrium, thus increasing the chances of implantation. In addition to that, it also builds a healthy amniotic sac and prevents its premature rupture.

3.Omega-3 Fatty Acids

While talking about supplements for implantation, omega-3 fatty acids have to deserve some room. Omega-3 fatty acids are a class of polyunsaturated fatty acids. As they cannot be synthesized by our body and have to be taken through diet, they fall under essential fatty acids
Some of the most important examples of this class of fatty acids include alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid. They can be derived from nuts, seafood, etc.
If sufficient omega-3 fatty acids cannot be supplied to the body through the diet, then supplements must be taken during pregnancy. They stimulate the production of nitric oxide inside the blood vessels, facilitating better blood flow to the uterus.
This makes the uterine environment suitable for implantation. In addition to that, omega-3 fatty acids help in the development of the brain of your baby and lower the chances of premature delivery.


L-arginine is a vital amino acid that can surprisingly raise the success rate of your IVF treatment. Amino acids are the building blocks of proteins. Usually, it is produced by the boy.
However, under physical stress, your body fails to synthesize enough of it. In such cases, it can be necessary to take arginine through diet or as supplements. Foods rich in arginine include nuts, pulses, meat, dairy, and so on.
After embryo transfer, you might be prescribed a dose of L-arginine. It is because, arginine improves blood flow to the uterus, thickens the endometrium, and makes it favorable for the embryo to be implanted.
This is because arginine gets converted into nitric oxide inside the blood vessels and causes them to relax which increases blood flow.


N-acetyl-cysteine is a potent supplement known to improve the chances of implantation. It increases the level of glutathione in the liver. Glutathione is the strongest antioxidant in the body and helps alleviate oxidative damage.
Damages caused to the cells of the endometrial lining due to oxidation of cell components often step in the way of implantation. N-acetyl-cysteine can come to a woman’s rescue in such cases.
In addition to these, this particular supplement influences the thickness of the endometrium which has a lot to do with implantation, as has been discussed multiple times earlier. Women with PCOS can also benefit from this as it increases the rate of ovulation and acts against insulin resistance.


Implantation is undoubtedly the determining factor in the success of your IVF treatment. If problems with the embryo have been ruled out then the next step is to make the uterine environment conducive enough to accept the embryo and help in its development.
Even though a balanced diet is enough to fulfill the dietary requirements of the body, sometimes supplements of essential vitamins and proteins are needed to prepare the body better for pregnancy.
Keeping that in mind, we discussed a few supplements to help implantation, IVF. however, make sure that you do not take any of these as per your whims. Consult a doctor and take only the prescribed doses for best results.

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